PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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X 7 days, p. The effects were compared with phenylbutazone mg kg -1 orally in carrageenin induced hind paw edema method and inflammxtory mg kg The test drug showed significant anti-inflammatory activity in dose dependant manner in both experimental models.

Lipid peroxidation is responsible for damaging cell membranes thereby further intensifying inflammatory damage. Indian Council of Medical Research India 2: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. The oxidative stress is the condition where Reactive Oxygen Species ROS generation exceeds endogenous anti-oxidant defense Sen, and it is well known that in chronic and sub-acute inflammation reactive oxygen species play an important role in modulating the extent of inflammatory response and consequent tissue and cell injury Robbin et al.

As, there are conflicting reports for the inflaammatory of anti-inflammatory activity of VN and it yet remain to be clearly explored against acute and sub-acute inflammation.

The results were compared with Group I. DX 7 days, orally as standard drug. Albino mice of either sex, kf gm were used to determine the lethal dose. This method is based on reduction in absorbance of a methanol solution of coloured free radical, 1,1-diphynylpicrylhydrazyl 7.

Group V received phenylbutazone mg kg -1 orally and Ibuprofen mg kg -1 B.

In carrageenin induced hind paw edema method, the oral administration of VN in graded dosesand mg kg -1 produced significant reduction in paw volume in dose dependent manner in comparison to control.

Used by Meir et al. Livingstone, Edinburgh and London. Springer Science and Business Media, Volume of the injected paw was measured plethysmographically immediately after viteex injection and then again at hourly intervals up to 4h. Oct 06, Abstract Vitex negundo and Murraya koenigii are popular Indian herbs which are used for various clinical disorders. Studies on lipid peroxides in platelets: The ethno medical use of V.


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Albino rats of either sex weight g of wistar strain, procured from National Institution of Nutrition, Hyderabad, India were used for the present study. They were fed ad libitum with rodents chow and free access to drinking water.

In this study, VN extract showed inhibiting effect on oxytocin induced rat uterus contractions in a dose dependent manner. International Journal of Pharmacology Volume 2 3: The fresh leaves of VN were cleaned of extraneous matter, shade dried and powdered.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

Ethanolic leaf extract of VN in the form of suspension was fed orally in a volume of 10 mL kg -1 wt. Oxytocin was dissolved in distilled water to get a desired concentration.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. These observations suggest VN to possess anti-inflammatory activity against acute inflqmmatory well as sub-acute inflammation which appears probably to be due to prostaglandin inhibition and reduction of oxidative stress respectively.

Ferrous sulphate, ascorbic acid, sodium chloride, potassium chloride, all of LR grade were obtained from local suppliers. Preliminary studies on antiinflammatory activity of Zingcher officinal Rosc.

Actovity cotton pellet granuloma test VN negjndo in graded dosesand mg kg Group I of cotton granulona test receiving distilled water served as diseased control.

Inhibitory effect of Vitex-negundo extract on oxytocin induced contractions in rat uterus in a dose dependant manner.

The extract also exhibited a strong free radical scavenging activity by 1,1-diphenylpicrylhydrazyl method and caused a significant reduction in the formation of thiobarbituric acid reacting substances when evaluated for its lipid peroxidation inhibitory activity.


J of Med and Aromat Plant Sci The present study therefore, intends to investigate the antiinflammatory activity of hydroalcoholic leaves extracts of polyhedral formulation unflammatory Murraya Koenigii and Vitex Negundo on carrageenan induced inflammation in experimental animal models, in order to confirm the medicinal properties of the plant. Wiley Series Chemistry and Pharmacology of Drugs.

Effects of Luffa echinata on lipid peroxidation and free Radical scavenging Activity.

Suspension of diclofenac sodium 6. After 7 days drug treatment in cotton pellet granuloma method, mL of blood was collected from inner canthus of eye from each animal using capillary tube, in a vial containing EDTA as an anticoagulant.

Antioxidant and Antiinflammatory Activity of Vitex negundo

The first phase is due to the release of histamine or serotonin, and the second phase is caused by the release of bradykinin, protease, prostaglandin, and lysosome. Animals Albino rates of either sex weighing gm were procured from Animal House of Kota College of Pharmacy, Kota, Rajasthan, and were selected in the study. Histomorphological changes induced by Vitex negundo in albino rats. Fundamental of Experimental Pharmacology. These findings were in agreement with the findings of Telang et al.

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Antioxidant and Antiinflammatory Activity of Vitex negundo.

The reaction mixture contained 0. Traditionally, the plant is used as a stimulant, stomachic, febrifuge, analgesic and for the treatment of diarrhoea, dysentery; insect bites and also used to allay heat of body [ 3 ]. The response of uterine tissue to oxytocin 0. The animals from cotton granuloma test were used in four groups with ndgundo animals in each group.

VN inhibited oxytocin induced contractions of rat uterus and plasma MDA malondialdehyde levels significantly.